The oral flea and tick preventives, Bravecto, NexGard, and Simparica, have been evaluated for their efficacy against Demodex canis. When the normal flea and tick preventative dose is administered as directed an excellent response against Demodex canis mites has been reported in peer reviewed journals.
Concurrent therapy with oral ivermectin is not contraindicated but should not be required. Most treated patients should resolve their demodicosis within a few months of therapy.
A recently published Journal article in Veterinary Parasitology demonstrated efficacy of Simparica for the treatment of sarcoptic mange in dogs.