Puppy Elkins: An Approach to Crusting Dermatitis

On initial presentation, “Puppy” was an otherwise healthy 5-year-old, spayed Boston Terrier with a progressive crusting dermatitis of several months’ duration. She was also moderately “itchy” where there were lesions. “Puppy” was treated with antibiotics by her primary care veterinarian for superficial bacterial folliculitis without any improvement in the lesion severity. Antihistamines were prescribed for itching but did not alleviate the issue. Puppy was referred to a veterinary dermatologist. Upon examination, there were widespread…

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Pemphigus Foliaceus in Cats: Symptoms and Treatment

Pemphigus foliaceus (PF) is the most common feline autoimmune skin disease. Pemphigus diseases result from the formation of antibodies against keratinocyte structures, and differ because each has a different target antigen and/or histopathologic feature. Epidermal cells have structures involved in cell-to-cell adhesion (desmosomes) or in cell-matrix adhesion (hemidesmosomes-anchoring fibrils complex). The desmosome is the component that holds keratinocytes (skin cells) together and is one structure in a dynamic system that support and connect cell…

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MDR1 Genetic Testing in Dogs

Collies, their crosses, other herding breeds, and other mixed breed dogs may possess a mutation in a gene that produces the protein, P-glycoprotein. P-glycoprotein is the product of the multi-drug resistance gene MDR-1. The functional protein plays an important role in absorption, distribution, metabolism, and excretion of many drugs and substances used in veterinary medicine. P-glycoprotein is a pump found in tissues of the intestine, brain, biliary system, kidneys, placenta, and testes. Its normal…

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